منابع مشابه
Immunity to avian influenza A viruses.
While the basic principles of immunity to the influenza A viruses are probably similar for all vertebrates, detailed understanding is based largely on experiments in laboratory mice. Elements of the innate response limit early virus replication, although high pathogenicity strains can trigger effusive cytokine/chemokine production and lethal shock. Virus clearance is normally mediated via CD8+ ...
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The nervous system is the target for acute encephalitic viral infections, as well as a reservoir for persisting viruses. Intrathecal antibody (Ab) synthesis is well documented in humans afflicted by infections associated with neurological complications, as well as the demyelinating disease, multiple sclerosis. This review focuses on the origin, recruitment, maintenance, and biological relevance...
متن کاملTumour viruses and innate immunity.
Host cells sense viral infection through pattern recognition receptors (PRRs), which detect pathogen-associated molecular patterns (PAMPs) and stimulate an innate immune response. PRRs are localized to several different cellular compartments and are stimulated by viral proteins and nucleic acids. PRR activation initiates signal transduction events that ultimately result in an inflammatory respo...
متن کاملEditorial: Plant Immunity against Viruses
Plant viruses, the simple obligate intracellular parasites with small genomes, rely entirely on host machineries for their life cycle including replication, intracellular (cell-to-cell) and systemic movement (Nelson and Citovsky, 2005). Virus infections pose serious threats to agriculture and cause huge economic losses. Despite encoding only a limited number of proteins, numerous interactions o...
متن کاملOriginal Antigenic Sin Response to RNA Viruses and Antiviral Immunity
The human immune system has evolved to fight against foreign pathogens. It plays a central role in the body's defense mechanism. However, the immune memory geared to fight off a previously recognized pathogen, tends to remember an original form of the pathogen when a variant form subsequently invades. This has been termed 'original antigenic sin'. This adverse immunological effect can alter vac...
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ژورنال
عنوان ژورنال: Current Opinion in Immunology
سال: 1989
ISSN: 0952-7915
DOI: 10.1016/0952-7915(88)90022-2